Rock, Paper, Shotgun has an interview with Thechineseroom's creative director Dan Pinchbeck, where they discuss Amnesia: A Machine for Pigs.
RPS: So itís a new setting, and new characters?
Pinchbeck: Yep. Itís 60 years later, the new game takes place on New Years Eve in 1899, in the streets of London, so itís full of mist, Steampunk, Victoriana. Itís set broadly in the same universe, but itís not a direct sequel, these arenít descendants of any of the characters. The underlying mythos of Amnesia is present, but making itself felt in another story, another time, another part of the world. Thatís been really great in term of making the game. Even if weíre not making it explicitly clear to the player, the logic of whatís going on, the development team are going ďWell that makes sense, because that would fit in there. There are bits where itís going to be interesting to see how direct a comparisson people draw. For us, weíve got this amazing playground, fictionally, to build this new stuff off. Because weíve gone that far forwards, it means we can do all kinds of other stuff, in terms of industrialisation, in terms of machines for pigs.